Constipation is not easily defined because there is wide inter-individual variation in normal bowel habit (the normal frequency of bowel motions may vary from three times per day to twice per week), but the term implies a diminished frequency of bowel motions and/or the passage of small hard stools.
Causes of constipation are many, and in an individual, may be multifactorial. Causes of constipation include: inadequate fibre intake, dehydration, immobility reduced muscle tone in small/large bowel, pregnancy, carcinoma, dementia, depression, hypercalcaemia and drugs.
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The 2009 RGH E-Bulletins are archived here.
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A joint initiative of the Patient Services Section and the Drug and Therapeutics Information Service of the Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia. The RGH Pharmacy E-Bulletin is distributed in electronic format on a weekly basis, and aims to present concise, factual information on issues of current interest in therapeutics, drug safety and cost-effective use of medications.
Editor: Assoc. Prof. Chris Alderman, University of South Australia – Director of Pharmacy, RGH © Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia 5041.
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Rivaroxaban is an oral direct factor Xa inhibitor in advanced clinical development for the prevention and treatment of thromboembolic disorders. As clinical use increases for this new drug it is important to be aware of factors influencing its clearance and hence anticoagulant potency. This is particularly important in the early part of the clinical use of a new drug, as sponsored clinical trials may have inclusion and exclusion criteria that might tend to be selective for healthier patients.
Download (PDF, 12.11KB)
The 2009 RGH E-Bulletins are archived here.
If you like this post and what else you see on the blog please subscribe by RSS feed (the orange button) or by email. Visit my subscription page.
A joint initiative of the Patient Services Section and the Drug and Therapeutics Information Service of the Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia. The RGH Pharmacy E-Bulletin is distributed in electronic format on a weekly basis, and aims to present concise, factual information on issues of current interest in therapeutics, drug safety and cost-effective use of medications.
Editor: Assoc. Prof. Chris Alderman, University of South Australia – Director of Pharmacy, RGH © Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia 5041.
Tagged as:
anticoagulation,
factor Xa,
RGH E-bulletin,
Rivaroxaban
