In excess of 70 million injections of iodinated contrast media are administered per year around the world. This approach is a diagnostic aid that has revolutionised clinical practice since its introduction in the 1950’s. Although generally considered relative safe, there is a possibility of adverse effects in the form of allergy like reactions in exposed patients.

Immediate reactions range from nausea, itching, urticaria, angioedema to more serious effects such as bronchoconstriction, laryngeal oedema, hypotension and death. Delayed reactions (three hours to a week after adm inistration) mainly include mild to moderate skin reactions. Reactions can occur after intravascular (e.g. cardiac procedures) and intracavitary administration (e.g. urology procedures).
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