Gout is a metabolic disease with symptoms arising from the deposition of monosodium urate crystals in joints and connective tissue tophi. Colchicine does not affect uric acid levels, but reduces the inflammatory reaction to urate crystals.
It may be used for pain relief in the acute treatment of gout and/or at lower doses for prophylaxis when urate-lowering treatment is initiated. Allopurinol is a xanthine oxidase inhibitor used to prevent gout attacks, acting by reducing urate levels through inhibition of the metabolism of xanthine to uric acid.
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