Confusion surrounds the prescribing of antimicrobials in renal impairment; whether to reduce the dose or extend the dosing interval. Suggested dose adjustments in renal impairment for many commonly used antibiotics are provided here, based on tables which can be found in the Therapeutic Guidelines (TG) Antibiotic, 14th edition.
No dose adjustment is required for some agents – these include azithromycin, roxithromycin, ceftriaxone, cefaclor, clindamycin, doxycycline, linezolid, moxifloxacin, phenoxymethylpenicillin, metronidazole among others.
A joint initiative of the Patient Services Section and the Drug and Therapeutics Information Service of the Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia. The RGH Pharmacy E-Bulletin is distributed in electronic format on a weekly basis, and aims to present concise, factual information on issues of current interest in therapeutics, drug safety and cost-effective use of medications.
Editor: Assoc. Prof. Chris Alderman, University of South Australia – Director of Pharmacy, RGH © Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia 5041.