Huntington’s disease – RGH Pharmacy E-Bulletin

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Huntington’s disease (HD) is a rare, inherited neurodegenerative disorder of the central nervous system, caused by an expansion in the trinucleotide CAG in the huntingtin gene.

Clinical features of the disease include involuntary choreiform movements, psychiatric disturbances, dementia, weight loss and circadian rhythm disturbances.

Multiple areas of the brain are affected by neuronal degeneration, with the predominantly affected neurotransmitters being dopamine, glutamate and GABA.

Read the complete bulletin:

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A joint initiative of the Patient Services Section and the Drug and Therapeutics Information Service of the Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia. The RGH Pharmacy E-Bulletin is distributed in electronic format on a weekly basis, and aims to present concise, factual information on issues of current interest in therapeutics, drug safety and cost-effective use of medications.
Editor: Assoc. Prof. Chris Alderman, University of South Australia – Director of Pharmacy, RGH © Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia 5041.

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