Huntington’s disease (HD) is a rare, inherited neurodegenerative disorder of the central nervous system, caused by an expansion in the trinucleotide CAG in the huntingtin gene.
Clinical features of the disease include involuntary choreiform movements, psychiatric disturbances, dementia, weight loss and circadian rhythm disturbances.
Multiple areas of the brain are affected by neuronal degeneration, with the predominantly affected neurotransmitters being dopamine, glutamate and GABA.
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Editor: Assoc. Prof. Chris Alderman, University of South Australia – Director of Pharmacy, RGH © Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia 5041.