Age-related macular degeneration (AMD) is the leading cause of blindness and severe visual impairment in adults over the age of 50. Neovascular AMD (nAMD) is caused by the growth of abnormal blood vessels under the macular which can cause haemorrhage and scarring, leading to severe vision loss. One of the mediators in the pathogenesis of neovascular AMD is vascular endothelial growth factor-A (VEGF) which facilitates the growth of these leaky blood vessels. New treatments have been developed to target the inhibition of this growth factor.
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Bevacizumab,
Macular degeneration,
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The Australian Advisory Committee on the Safety of Medicines (ACSOM) have received few reports of renal
impairment/failure with IV pamidronate, or oral bisphosphonates risedronate and alendronate, but a significant number with zoledronic acid (31 from a total of 268 reports) are reported. Deterioration in renal function with IV bisphosphonates due to a rapid infusion rate has been suggested, but the reports did not appear to be related to a rapid infusion rate.
Interstitial nephritis was described in three reports. It is important to bear in mind that those who received zoledronic acid were probably more likely predisposed to renal failure secondary to existing co-morbidities (many patients had pre-existing renal impairment or multiple myeloma).
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Bisphosphonates,
kidney,
osteoporosis,
renal,
RGH E-bulletin,
zoledronic acid
