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Atrial Fibrillation

Interaction

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used drug groups worldwide. Gastrointestinal toxicity, renal impairment and heart failure associated with these drugs have been a concern for some time. The risk of myocardial infarction associated with NSAIDs has also been highlighted. More recently there has been focus on the association of NSAIDs with atrial fibrillation (AF).

Download the complete bulletin:

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A joint initiative of the Patient Services Section and the Drug and Therapeutics Information Service of the Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia. The RGH Pharmacy E-Bulletin is distributed in electronic format on a weekly basis, and aims to present concise, factual information on issues of current interest in therapeutics, drug safety and cost-effective use of medications.

Editor: Assoc. Prof. Chris Alderman, University of South Australia – Director of Pharmacy, RGH © Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia 5041.

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InteractionEach year it seems two questions on cardiovascular disease are always asked. ‘What is the role of B-blockers in treating hypertension?’ and ‘Is rate control or rhythm control best in the management of Atrial Fibrillation?’ The latter is the subject of the latest RGH bulletin.

The recent publication of several studies, such as the AFFIRM and RACE study, which compared rhythm control with rate control in patients older than 65 years old, led to the conclusion that rhythm control is not superior to rate control as it neither improves patient survival rate or functional status nor reduces the risk of stroke in patients with AF.

Download (PDF, 92.46KB)

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