There has been a lot of discussion lately about the interaction between clopidogrel and the proton pump inhibitors (eg omperazole).
Clopidogrel is an antiplatelet drug. Well it is not really a drug. It is a prodrug and needs to be converted to an active metabolite in the liver. If you can get something to reduce Cytochrome CYP2C19 then clopidogrel is not metabolised and so no antiplatelet action occurs.
Yes you got it. The proton pump inhibitors can inhibit CYP2C19.
This bulletin from the Repatriation General Hospital in Adelaide sums up the latest evidence. Click on the picture below to download the small pdf.
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