Posts tagged as:

drugs

Drug-induced photosensitivity reactions – RGH E-Bulletin

by Robbo on November 18, 2011

Drug induced photosensitivity reactions are a relatively common side effect associated with many medications. These reactions occur via activation of a chemical by ultra-violet or visible light. Many commonly used drugs are implicated (both systemic and topical use), and include amiodarone, NSAIDs, phenothiazines, retinoids, quinolones, sulfonamides, tetracyclines, and thiazides.

Download the complete bulletin:

Download (PDF, 17.48KB)

A joint initiative of the Patient Services Section and the Drug and Therapeutics Information Service of the Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia. The RGH Pharmacy E-Bulletin is distributed in electronic format on a weekly basis, and aims to present concise, factual information on issues of current interest in therapeutics, drug safety and cost-effective use of medications.
Editor: Assoc. Prof. Chris Alderman, University of South Australia – Director of Pharmacy, RGH © Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia 5041.

Tagged as: amiodarone, drugs, Medications, NSAIDs, phenothiazines, photosensitivity, quinolones, retinoids, RGH E-bulletin, sulfonamides, tetracyclines

{ 0 comments }

RGH E-Bulletin: Drug-Induced Myopathies

by Robbo on February 8, 2010

in Drug Information

Drug-induced myopathies may present in varying degrees of severity from mild muscle weakness to rhabdomyolysis with acute renal failure. Drugs may cause myopathic symptoms by directly affecting a muscle organelle, inducing immunological or inflammatory myopathy, altering systemic functions leading to electrolyte disturbances or via nutritional deprivation, and this in turn affects muscle function. Many toxic myopathies are reversible, thus prompt detection of the offending agent is essential. These are some common drugs implicated in this condition

Download (PDF, 11.3KB)

Tagged as: Antirheumatic, drugs, Glucocorticoids, muscle weakness, myopathies, myopathy, nucleoside reverse transcriptase inhibitors, renal failure, RGH E-bulletin, rhabdomyolysis, Zidovudine

{ 2 comments }

Drug Deaths and Media Hysteria

by Robbo on November 20, 2009

in Drug Information

Information is Beautiful is one of my favourite blogs. Interesting data in beautiful and easy to take in visual presentations.

A recent post looked at the poisoning deaths in the UK and then compared them to the number of press reports the drug deaths received.

It was very interesting. Some drugs received an extraordinary number of mentions when a death occured as a result of misadventure. Deaths due to heroin had only 9% of deaths reported. Cocaine with a little over a quarter of the number of deaths compared to heroin had 66% of all deaths reported. The number of press reports for cocaine doubled those of heroin.

My personal favourites are aspirin and cannabis where the press reported more often than people died. In the case of cannabis almost five times as much.

Media Hysteria or public interest?

Unfortunately I believe these results would be replicated in Australia.

If you like this post and what else you see on the blog please subscribe by RSS feed (the orange button) or by email. Visit my subscription page.

Tagged as: Deadly Drugs, deaths, drugs, informationisbeautiful.net, misadventure, visualisation

{ 8 comments }

Data Loggers

by Robbo on January 12, 2009

in Drug Information,Gear,Remote health

Warning: This post is for those with a fetish for dataloggers.

I had a couple of enquiries about what sort of data loggers I use for Quality Assurance. So here we go.

I have yet to find the perfect data logger. I have used several and haven’t been 100% happy with any of them.It seems I will have to use different loggers for different tasks.

We have 11 clinics with multiple fridges in each clinic. Loggers are to go at random in fridges and also be placed on stock shelves. Loggers are also in the doctor emergency bags which spend a lot of time in and out of hot vehicles. We source pharmacy supplies from several different pharmacies/pharmacy departments depending on item and destination of delivery and our internal mail bags also carry some items. I have already posted about the temperatures our cold chain needs to handle while in light aeroplanes and also how we are starting to move refrigerated drugs around the lands

What do I want in a Data Logger?

TinyTag Loggers

(from Hasting Data Loggers)

These are splashproof and have no plugs, rather using an induction pad. They can be started on delay or using a magnet and they automatically stop after a certain number of readings, or when full. Unfortunately they only take 8000 readings so do not suit my needs monitoring drug rooms and fridges.

Being splashproof they are ideal for use in eskies as we bring refrigerated items onto the lands. However, an inability to switch the item off when received at the clinic makes them of no use. My aim is not to have extra software and plugs at clinics as I use the data for quality control purposes, not just to monitor the temperature integrity during transport. There is also no alarm to indicate the temperature has been too high or low.

TransiTempII

(from Madgetech)

These are good value. Unfortunately they have no push button start/stop but rely on computer software or a magnet to commence and cease temperature recording. This makes them unacceptable for use with third parties starting them in a pharmacy and then a nurse stopping the logger before forwarding it on to have the data used for Quality Assurance purposes.

They do hold over 32000 readings and are splashproof. There are warning and alert lights. A green light signifies the logger has stored temperatures between the set temperatures. There is amber warning light and red alert light. For refrigerated items I have them set for a warning light at 3 and 7C and the alert light to flash below 2C or 8C.

I will continue to use these for long term monitoring where I can download data on a regular visit.

Temp 100

(from Madgetech)

These have an on/off switch! However they are not splashproof so cannot be used in fridges or refrigerated items in transit. We have used these in a drug room data logging project. High and low limits can be set with an LED going from green to red should the limits be exceeded. They are also a lot more expensive than the TransitempII. we will not be using these again.

It seems to have the benefit of an on/off switch and be splashproof I may be up for several hundreds of dollars each meter which will limit the numbers we be able to use to monitor goods in transit.

Using a variety of loggers means there is a variety of software and a variety of cables required, even sometimes if the profit is from the same company. Purchasing from one company will make it easier to have the loggers recalibrated on a regular basis.

Unfortunately the use of the loggers will not replace the use of the chemical heat and freeze indicators in the drug fridges. I have come across several incidences where the fridge temperature readings have been normal, but items frozen, or overheated at the top or bottom of the fridge. This can occur due to fan failures or temperature probe failures.

If you like this post and what else you see on the blog please subscribe by RSS feed (the orange button) or by email. The email subscription is just under my profile picture. Or you can visit my subscription page.