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interactions

Interaction

In Australia, pharmacists use Cautionary and Advisory Labels (CALs) when dispensing to provide written reinforcement of important counselling points for particular medicines. The 10a CAL “Do not take more than one aspirin tablet or capsule each day while being treated with this medicine” is used for a number of medications that are reported to interact with aspirin (with the exception of warfarin which is labelled with the 10b CAL “Do not take aspirin while being treated with this medicine unless advised by your doctor”). Whilst some medications that interact with aspirin are well known, others are less so. Some of these medications and the reason behind their interaction are summarised in the table below.

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The 2009 RGH E-Bulletins are archived here.

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A joint initiative of the Patient Services Section and the Drug and Therapeutics Information Service of the Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia. The RGH Pharmacy E-Bulletin is distributed in electronic format on a weekly basis, and aims to present concise, factual information on issues of current interest in therapeutics, drug safety and cost-effective use of medications.
Editor: Assoc. Prof. Chris Alderman, University of South Australia – Director of Pharmacy, RGH © Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia 5041.

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Interaction

Gout is a metabolic disease with symptoms arising from the deposition of monosodium urate crystals in joints and connective tissue tophi. Colchicine does not affect uric acid levels, but reduces the inflammatory reaction to urate crystals.

It may be used for pain relief in the acute treatment of gout and/or at lower doses for prophylaxis when urate-lowering treatment is initiated. Allopurinol is a xanthine oxidase inhibitor used to prevent gout attacks, acting by reducing urate levels through inhibition of the metabolism of xanthine to uric acid.

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