Huntington’s disease – RGH Pharmacy E-Bulletin

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Huntington’s disease (HD) is a rare, inherited neurodegenerative disorder of the central nervous system, caused by an expansion in the trinucleotide CAG in the huntingtin gene.

Clinical features of the disease include involuntary choreiform movements, psychiatric disturbances, dementia, weight loss and circadian rhythm disturbances.

Multiple areas of the brain are affected by neuronal degeneration, with the predominantly affected neurotransmitters being dopamine, glutamate and GABA.

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A joint initiative of the Patient Services Section and the Drug and Therapeutics Information Service of the Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia. The RGH Pharmacy E-Bulletin is distributed in electronic format on a weekly basis, and aims to present concise, factual information on issues of current interest in therapeutics, drug safety and cost-effective use of medications.
Editor: Assoc. Prof. Chris Alderman, University of South Australia – Director of Pharmacy, RGH © Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia 5041.

Crushing solid oral medicines – RGH Pharmacy E-Bulletin

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There is a 40-50% prevalence of dysphagia among elderly people in residential aged care facilities. Age related, or drug-induced xerostomia may be a cause of difficulty swallowing along with medical conditions such as stroke, Parkinson’s disease and motor neurone disease.

Read the complete bulletin:

Download (PDF, 18KB)

A joint initiative of the Patient Services Section and the Drug and Therapeutics Information Service of the Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia. The RGH Pharmacy E-Bulletin is distributed in electronic format on a weekly basis, and aims to present concise, factual information on issues of current interest in therapeutics, drug safety and cost-effective use of medications.
Editor: Assoc. Prof. Chris Alderman, University of South Australia – Director of Pharmacy, RGH © Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia 5041.

Use of LMWH in patients with advanced liver cirrhosis – RGH Pharmacy E-Bulletin

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Low molecular weight heparins (LMWH) are commonly used in the prophylaxis and treatment of venous thromboembolic (VTE) diseases. However, there is limited evidence to guide the use of LMWH in patients with advanced liver cirrhosis.

Read the complete bulletin:

Download (PDF, 18KB)

A joint initiative of the Patient Services Section and the Drug and Therapeutics Information Service of the Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia. The RGH Pharmacy E-Bulletin is distributed in electronic format on a weekly basis, and aims to present concise, factual information on issues of current interest in therapeutics, drug safety and cost-effective use of medications.
Editor: Assoc. Prof. Chris Alderman, University of South Australia – Director of Pharmacy, RGH © Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia 5041.

Antibiotics in renal impairment – RGH Pharmacy E-Bulletin

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Confusion surrounds the prescribing of antimicrobials in renal impairment; whether to reduce the dose or extend the dosing interval. Suggested dose adjustments in renal impairment for many commonly used antibiotics are provided here, based on tables which can be found in the Therapeutic Guidelines (TG) Antibiotic, 14th edition.

No dose adjustment is required for some agents – these include azithromycin, roxithromycin, ceftriaxone, cefaclor, clindamycin, doxycycline, linezolid, moxifloxacin, phenoxymethylpenicillin, metronidazole among others.

Download (PDF, 19KB)

A joint initiative of the Patient Services Section and the Drug and Therapeutics Information Service of the Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia. The RGH Pharmacy E-Bulletin is distributed in electronic format on a weekly basis, and aims to present concise, factual information on issues of current interest in therapeutics, drug safety and cost-effective use of medications.
Editor: Assoc. Prof. Chris Alderman, University of South Australia – Director of Pharmacy, RGH © Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia 5041.

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