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Treatment-Emergent Affective Switch

InteractionThat’s got to be one of the better titles for a blog post! But it is quite a serious topic and is an effect that may occur in up to 40% of bipolar patients with antidepressants.

From the bulletin:

The treatment with antidepressants may be associated with the induction of episodes of mania or hypomania in 15-40% of bipolar patients. The phenomenon of abnormal mood elevation during antidepressant treatment, or ‘treatment-emergent affective switch’ was first described in association with tricyclic antidepressants, and has now been reported for all major antidepressant classes.

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